Why Are Elephants Considered For Cancer Research - 766 Words

Abeggien L, Caulin A, Chan A, Lee K, Robinson R, Campbell M, Kiso W, Schmitt D, Waddell P, Bhaskara S, Jensen S, Maley C, Schiffman J (2015) Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA. 314(17):1850-1860.doi:10.1001/jama.2015.13134 Questions 1. Why were elephants considered for cancer research? 2. Why might elephants have evolved to be more resistant to cancers than other mammals? 3. Are there other mammals possessing multiple copies of p53 genes? 4. How is p53 expressed when there are multiple copies? 5. What are the implications of this research for medicine? The article states that the importance of the research is to gainâ€Å"insights into human physiology and pathophysiology, including tumor biology† through research of evolutionary medicine. The objective of the research as stated by the article is to â€Å"identify mechanisms for cancer resistance in elephants and compare cellular response to DNA damage among elephants, healthy human controls, and cancer-prone patients with Li-Fraumeni syndrome.† Persons with Li-Fraumeni syndrome have a 90% risk of cancer in their lifetime. Li-Fraumeni syndrome is an inherited autosomal dominant disorder in which the TP53 gene on one of the homologs of chromosome 17 is mutated usually passed on from a mutation in germ line cells. TP53 is a tumor suppressor gene which codes for p53, a nucleophosphoprotein that is able to bind toShow MoreRelatedEssay about The Ethics and Limitations of Animal Research 1550 Words   |  7 Pagesscience and medicine to develop so without animal research ( â€Å"The Use of Non-Human Animals in Research†, 2004). Nevertheless, do the human medical benefits really justify the animal suffering in animal research? 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